WinNonlin for Win95/WinNT (32-bit)
Special Sub Menu
S
pecial
Change Variable Offset - Displays a dialog box where you may choose to subtract (or not subtract) the value of
d
c (DeltaY) from the data when plotting. This is most useful in the case of interference data where there is always an arbitrary offset included in the values of the concentration.
Change Speed or Concentration Factors - Displays a dialog box for changing the speed and concentration factors. The speed factor (SF) is used to allow joint fitting of data sets from different speeds. This factor is the ratio of [(1-v
*r
)*
w
2
)/(RT)]
speed(i)
to [(1-v
*r
)*
w
2
)/(RT)]
ref. speed
. For example, to combine data from speeds of 10K rpm (ref. speed) and 20K rpm you would use a SF of 1.0 for the 10K data and a SF of 4.0 for the 20K data. The concentration factor (CF) can be used to allow joint fitting of data sets using absorption at one or more wavelengths along with data from the interference optical system. One only needs to know the extinction coefficient(s) at the wavelength(s) used and the conversion factor for fringes to gm/L (for the XL-I this is 3.26 fringes/gm/L for most proteins, for a 1.2 cm path length cell.). For example, to combine data taken at a wavelength where the absorption coefficient is 0.80 OD/gm/L with interference data then you would use a CF of 1.25 (1/0.80) for the absorbance data and a CF of 0.307 (1/3.26) for the interference data to convert them both to concentration units of gm/L.
Save ListFile - Allows you to save to a file a list of all the current data files. This list file can then be used to load these same files during a future fitting session (see Input File Names:
L
ist Files: File Names Only).
Save ListFile & Current Fit - Allows you to save to a file a "snapshot" of the current fitting session which can then be used to restore WinNonlin to the same state during a future session (see Input File Names:
L
ist Files: File Names & Fit).
Start Saving Deviations / Stop Saving Deviations - Starts and stops the savings of a table of the deviations of data from the calculated fit to the output file.
Dump Moments or Concentrations - Allows you to save to a file either the various moments or species concentrations for all of the current active data sets, using the current model and values for the fitted parameters.
Save Parameters - Allows you to save the current fitting parameters to a temporary array (up to 39 sets of parameters) which can then be restored at any time during the current session. An option is also available to save the parameter set to a file which can be used at any time.
Restore Parameters - Allows you to restore a previously saved set of fitting parameters.
Restore From File - Allows you to restore a set of fitting parameters which has been saved to a file.
Select Active DataSets - Allows you to inactivate/activate any currently loaded data set (at least one set must remain active).
V1.035 - Limited Editing Capability
Select XI range - Allows you to set the lower and upper limits for XI (R
2
/2) for all data sets by entering in new values for XI
low
and XI
high
. See
E
dit Data
to set the limits graphically.
V1.050 & V1.060 - Full Editing Capability
Set Global Conc. Limits - Allows you to set global upper and lower limits for the concentration. The concentration limits for each data set are scaled by the appropriate concentration factor after first being corrected by the value of the offset (
d
c or DeltaY). These limits are displayed on the
Edit Window
if they fall within the current range of the plot.
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