WinNonlin for Win95/WinNT (32-bit)
Fitting Sub Menu


 
 
  • Fitting
  • Fit Data  -  Starts the fitting process.  If this is the first attempt at fitting then a dialog box will be shown to set the concentration units for the plot labels and a second dialog box will then be displayed for entering the speed and concentration factors.  Speed and concentration factors can be used to allow joint fitting of data from different speeds, different optical systems or different wavelengths (see Special: Change Speed or Conc. Factors for more detail).
  • Common Ks  -  Allows you to select, via a dialog box, to use either common (default) or individual values for the various LnK’s.  Normally one assumes that the values of the equilibrium constants should be independent of the loading concentration and speed.  If a fit of multiple data sets exhibits self-association and the fit of the data to a model which allows individual equilibrium constants for each set results in a statistically significant  better fit then this may be an indication of a heterogeneous sample.  This could result from, among other things, the presence of some non-reacting species - an incompetent monomer, non-dissociating polymeric form or some other contaminant.
  • Convergence Params  -  Allows you to change the convergence parameter, the confidence interval for calculation of the confidence range and the formula used to calculate the error statistics for the fit.
  • Check All DeltaY, LnA + Sigma  -  Selects all of these parameters to be fitted.
  •   
    Previous         Next